A Novel Mutation of GFAP Causing Adult-Onset Alexander Disease

A Novel Mutation of GFAP Causing Adult-Onset Alexander Disease

Alexander disease (AxD) is a rare, autosomal dominant neurological disorder. Three clinical subtypes are distinguished based on age at onset: infantile (0–2 years), juvenile (2–13 years), and adult (>13 years). The three forms differ in symptoms and prognosis. Rapid neurological decline with...

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Bibliographic Details
Main Authors: Andrea Ciammola, Davide Sangalli, Jenny Sassone, Barbara Poletti, Laura Carelli, Paolo Banfi, Gabriele Pappacoda, Isabella Ceccherini, Alice Grossi, Luca Maderna, Monica Pingue, Floriano Girotti, Vincenzo Silani
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neurology
Subjects:
Alexander disease
GFAP-glial fibrillary acidic protein
leukodystrophy
gene mutation
adult onset
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01124/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.01124/full

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