Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15.

Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15.

Over-expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes (PED/PEA-15) causes insulin resistance by interacting with the D4 domain of phospholipase D1 (PLD1). Indeed, the disruption of this association restores insulin sensitivity in cultured cells over-expressing...

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Main Authors: Angela Cassese, Gregory A Raciti, Francesca Fiory, Cecilia Nigro, Luca Ulianich, Ilenia Castanò, Vittoria D'Esposito, Daniela Terracciano, Lucio Pastore, Pietro Formisano, Francesco Beguinot, Claudia Miele
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3621763?pdf=render

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http://europepmc.org/articles/PMC3621763?pdf=render

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