Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock — rationale and design of a multicenter randomized controlled superiority trial

Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock — rationale and design of a multicenter randomized controlled superiority trial

Abstract Background Antibiotic exposure is often inadequate in critically ill patients with severe sepsis or septic shock and this is associated with worse outcomes. Despite markedly altered and rapidly changing pharmacokinetics in these patients, guidelines and clinicians continue to rely on standa...

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Bibliographic Details
Main Authors: Luca F. Roggeveen, Lucas M. Fleuren, Tingjie Guo, Patrick Thoral, Harm Jan de Grooth, Eleonora L. Swart, Thomas L. T. Klausch, Peter H. J. van der Voort, Armand R. J. Girbes, Rob J. Bosman, Paul W. G. Elbers
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Trials
Subjects:
Personalized medicine
Antibiotic dosing
Clinical decision support
Intensive care medicine
Pharmacokinetics
Data science
Online Access:https://doi.org/10.1186/s13063-019-3911-5

Internet

https://doi.org/10.1186/s13063-019-3911-5

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