Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

The downregulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the Sost gene hours after stimulation. Using mouse model...

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Bibliographic Details
Main Authors: Nicole R Gould, Katrina M Williams, Humberto C Joca, Olivia M Torre, James S Lyons, Jenna M Leser, Manasa P Srikanth, Marcus Hughes, Ramzi J Khairallah, Ricardo A Feldman, Christopher W Ward, Joseph P Stains
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
osteocyte
sclerostin
parathyroid hormone
lysosome
mechanical load
bone
Online Access:https://elifesciences.org/articles/64393

Internet

https://elifesciences.org/articles/64393

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