Equilibrium of the intracellular redox state for improving cell growth and l-lysine yield of Corynebacterium glutamicum by optimal cofactor swapping

Equilibrium of the intracellular redox state for improving cell growth and l-lysine yield of Corynebacterium glutamicum by optimal cofactor swapping

Abstract Background NAD(H/+) and NADP(H/+) are the most important redox cofactors in bacteria. However, the intracellular redox balance is in advantage of the cell growth and production of NAD(P)H-dependent products. Results In this paper, we rationally engineered glyceraldehyde-3-phosphate dehydrog...

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Bibliographic Details
Main Authors: Jian-Zhong Xu, Hao-Zhe Ruan, Xiu-Lai Chen, Feng Zhang, Weiguo Zhang
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Microbial Cell Factories
Subjects:
Corynebacterium glutamicum
Glyceraldehyde-3-phosphate dehydrogenase
Isocitrate dehydrogenase
Redox state
Cofactor optimization
l-Lysine production
Online Access:http://link.springer.com/article/10.1186/s12934-019-1114-0

Internet

http://link.springer.com/article/10.1186/s12934-019-1114-0

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