Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities

Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities

Abstract Background Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Of the three, HAS1 is found to be localized more into the cytoplasmic space where it synthesizes intracellular HA. HA is a ubiquitous glycosaminoglycan...

Full description

Bibliographic Details
Main Authors: Nguyet Nguyen, Awanit Kumar, Simi Chacko, Rodney J. Ouellette, Anirban Ghosh
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Cell Communication and Signaling
Subjects:
Hyaluronic acid Synthase-1
Malignant transformation
Epithelial-to-Mesenchymal transition
Genetic heterogeneity
Genomic instability
Micronucleus
Online Access:http://link.springer.com/article/10.1186/s12964-017-0204-z

Internet

http://link.springer.com/article/10.1186/s12964-017-0204-z

Similar Items