The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices

The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices

Background: The functional interplay between tumor cells and their adjacent stroma has been suggested to play crucial roles in the initiation and progression of tumors and the effectiveness of chemotherapy. The extracellular matrix (ECM), a complex network of extracellular proteins, provides both ph...

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Bibliographic Details
Main Authors: Dimakatso Alice Senthebane, Tina Jonker, Arielle Rowe, Nicholas Ekow Thomford, Daniella Munro, Collet Dandara, Ambroise Wonkam, Dhirendra Govender, Bridget Calder, Nelson C. Soares, Jonathan M. Blackburn, M. Iqbal Parker, Kevin Dzobo
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
esophageal cancer
3D extracellular matrix
stroma
type I collagen
fibronectin
chemoresistance
signaling cascade
targeted therapy
Online Access:http://www.mdpi.com/1422-0067/19/10/2861

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http://www.mdpi.com/1422-0067/19/10/2861

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