NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice

NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice

Abstract Background Parkinson’s disease (PD), the most common neurodegenerative movement disorder, is characterized by dopaminergic nigrostriatal neuron loss and brain accumulation of Lewy bodies, protein aggregates mainly composed of α-synuclein. We reported that mice deficient for NF-κB/c-Rel (c-r...

Full description

Bibliographic Details
Main Authors: Edoardo Parrella, Arianna Bellucci, Vanessa Porrini, Marina Benarese, Annamaria Lanzillotta, Gaia Faustini, Francesca Longhena, Giulia Abate, Daniela Uberti, Marina Pizzi
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Translational Neurodegeneration
Subjects:
Parkinson’s disease
NF-κB/c-Rel
non-motor symptoms
α-synuclein
pathology progression
Online Access:http://link.springer.com/article/10.1186/s40035-019-0154-z

Internet

http://link.springer.com/article/10.1186/s40035-019-0154-z

Similar Items