The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII

The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII

Abstract Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as drivers in sub-populations of a wide-range of human cancers. This, combined with a recent report that both adult and childhood cancers driven by novel oncogenic TrkA chimeric-fusions exhibit profound, lo...

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Bibliographic Details
Main Authors: Antonietta Rosella Farina, Lucia Cappabianca, Pierdomenico Ruggeri, Luciana Gneo, Cristina Pellegrini, Maria-Concetta Fargnoli, Andrew Reay Mackay
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TrkAIII
Alternative splicing
Neuroblastoma
Oncogenic signaling
Unfolded protein response
Warburg effect
Online Access:http://link.springer.com/article/10.1186/s13046-018-0786-3

Internet

http://link.springer.com/article/10.1186/s13046-018-0786-3

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