Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae

Mosaic interspecifically acquired alleles of the multiple transferable resistance (mtr) efflux pump operon correlate with increased resistance to azithromycin in Neisseria gonorrhoeae in epidemiological studies. However, whether and how these alleles cause resistance is unclear. Here, we use populat...

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Bibliographic Details
Main Authors: Crista B. Wadsworth, Brian J. Arnold, Mohamad R. Abdul Sater, Yonatan H. Grad
Format: Article
Language:English
Published: American Society for Microbiology 2018-08-01
Series:mBio
Subjects:
Neisseria gonorrhoeae
antibiotic resistance
efflux pump
epistasis
gonorrhea
macrolide
Online Access:https://doi.org/10.1128/mBio.01419-18

Internet

https://doi.org/10.1128/mBio.01419-18

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