Follicular Helper T Cells Remodel the Immune Microenvironment of Pancreatic Cancer via Secreting CXCL13 and IL-21

Follicular Helper T Cells Remodel the Immune Microenvironment of Pancreatic Cancer via Secreting CXCL13 and IL-21

Immunosuppression is an important factor for the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Follicular helper T cells (Tfh cells) play an anti-tumor role in various malignant solid tumors and predict better patient prognosis. In the present study, we aimed to determine the immunosupp...

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Bibliographic Details
Main Authors: Xuan Lin, Longyun Ye, Xu Wang, Zhenyu Liao, Jia Dong, Ying Yang, Rulin Zhang, Hao Li, Pengcheng Li, Lei Ding, Tianjiao Li, Wuhu Zhang, Shuaishuai Xu, Xuan Han, Huaxiang Xu, Wenquan Wang, Heli Gao, Xianjun Yu, Liang Liu
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
follicular helper T cells
immune microenvironment
immunosuppression
neoadjuvant chemotherapy
pancreatic ductal adenocarcinoma
Online Access:https://www.mdpi.com/2072-6694/13/15/3678

Internet

https://www.mdpi.com/2072-6694/13/15/3678

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