High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma

High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma

Head and neck paragangliomas (HNPGLs) are rare neoplasms that represent difficult treatment paradigms in neurotology. Germline mutations in genes encoding succinate dehydrogenase (SDH) are the cause of nearly all familial HNPGLs. However, the molecular mechanisms underlying tumorigenesis remain uncl...

Full description

Bibliographic Details
Main Authors: Zhigang Wang, Hongsai Chen, Lu Xue, Weiwei He, Wenying Shu, Hao Wu, Zhaoyan Wang
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Translational Oncology
Subjects:
Head and neck paragangliomas
Proteomics
Metabolomics
SDH
Metformin
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001388

Internet

http://www.sciencedirect.com/science/article/pii/S1936523321001388

Similar Items