A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model

A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model

The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotyp...

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Bibliographic Details
Main Authors: Lisa M. Plitnick, Beth Hutchins, Sheri Dubey, Nianyu Li, Rupesh P. Amin, Stephanie Born, Ruban Mangadu, Joseph H. Phillips, Venkataraman Sriram, Danuta J. Herzyk
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Immunotoxicology
Subjects:
anti-pd-1
vaccination
murine
alternate model
Online Access:http://dx.doi.org/10.1080/1547691X.2020.1826020

Internet

http://dx.doi.org/10.1080/1547691X.2020.1826020

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