The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates

The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates

Abstract Background Plasmodium falciparum resistance to artemisinin-based combination therapy has emerged and spread in Southeast Asia. In areas where artemisinin resistance is emerging, the efficacy of combination is now based on partner drugs. In this context, the identification of novel markers o...

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Bibliographic Details
Main Authors: Mathieu Gendrot, Francis Tsombeng Foguim, Marie Gladys Robert, Rémy Amalvict, Joel Mosnier, Nicolas Benoit, Marylin Madamet, Bruno Pradines, the French National Reference Centre for Imported Malaria Study Group
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
Anti-malarial drug
In vitro
Resistance
Molecular marker
Online Access:http://link.springer.com/article/10.1186/s12936-018-2252-2

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http://link.springer.com/article/10.1186/s12936-018-2252-2

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