Amorphous, Smart, and Bioinspired Polyphosphate Nano/Microparticles: A Biomaterial for Regeneration and Repair of Osteo-Articular Impairments In-Situ

Amorphous, Smart, and Bioinspired Polyphosphate Nano/Microparticles: A Biomaterial for Regeneration and Repair of Osteo-Articular Impairments In-Situ

Using femur explants from mice as an in vitro model, we investigated the effect of the physiological polymer, inorganic polyphosphate (polyP), on differentiation of the cells of the bone marrow in their natural microenvironment into the osteogenic and chondrogenic lineages. In the form of amorphous...

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Bibliographic Details
Main Authors: Werner E. G. Müller, Meik Neufurth, Shunfeng Wang, Maximilian Ackermann, Rafael Muñoz-Espí, Qingling Feng, Qiang Lu, Heinz C. Schröder, Xiaohong Wang
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
long bone defects
bone marrow cells
inorganic polyphosphate
microparticles
bisphosphonates
Runx2
Sox9
cathepsin-K
tumor metastases
human mesenchymal stem cells
Online Access:http://www.mdpi.com/1422-0067/19/2/427

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http://www.mdpi.com/1422-0067/19/2/427

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