The hydroxypropyl‐β‐cyclodextrin‐minoxidil inclusion complex improves the cardiovascular and proliferative adverse effects of minoxidil in male rats: Implications in the treatment of alopecia

The hydroxypropyl‐β‐cyclodextrin‐minoxidil inclusion complex improves the cardiovascular and proliferative adverse effects of minoxidil in male rats: Implications in the treatment of alopecia

Abstract The efficacy of minoxidil (MXD) ethanolic solutions (1%‐5% w/v) in the treatment of androgenetic alopecia is limited by adverse reactions. The toxicological effects of repeated topical applications of escalating dose (0.035%‐3.5% w/v) and of single and twice daily doses (3.5% w/v) of a nove...

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Bibliographic Details
Main Authors: Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Nunzio Denora, Giuseppe Passantino, Rosa Scala, Annalisa Cutrignelli, Antonella Tinelli, Valentino Laquintana, Flavia laForgia, Sergio Fontana, Massimo Franco, Angela Assunta Lopedota, Domenico Tricarico
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Pharmacology Research & Perspectives
Subjects:
androgenic alopecia
ATP‐sensitive potassium channels
cell proliferation
minoxidil
toxicology
Online Access:https://doi.org/10.1002/prp2.585

Internet

https://doi.org/10.1002/prp2.585

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