Decreased protein binding of moxifloxacin in patients with sepsis?

Decreased protein binding of moxifloxacin in patients with sepsis?

The mean (SD) unbound fraction of moxifloxacin in plasma from patients with severe sepsis or septic shock was determined by ultrafiltration to 85.5±3.0% (range 81.9 and 91.6%) indicating a decreased protein binding of moxifloxacin in this population compared with the value of 58–60% provided in the...

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Bibliographic Details
Main Authors: Dorn, Christoph, Nowak, Hartmuth, Weidemann, Caroline, Martini, Stefan, Zeitlinger, Markus, Adamzik, Michael, Kees, Frieder
Format: Article
Language:English
Published: German Medical Science GMS Publishing House 2017-02-01
Series:GMS Infectious Diseases
Subjects:
fluoroquinolone
unbound fraction
ultrafiltration
septic shock
Online Access:http://www.egms.de/static/en/journals/id/2017-5/id000029.shtml

Internet

http://www.egms.de/static/en/journals/id/2017-5/id000029.shtml

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