Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis.

The complex interactions between recurrent trypsin-mediated pancreatic injury, alcohol-associated pancreatic injury and SPINK1 polymorphisms in chronic pancreatitis (CP) are undefined. We hypothesize that CP occurs as a result of multiple pathological mechanisms (pathways) that are initiated by diff...

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Bibliographic Details
Main Authors: Elie Aoun, Chung-Chou H Chang, Julia B Greer, Georgios I Papachristou, M Michael Barmada, David C Whitcomb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2289874?pdf=render