Metformin-Enhanced Cardiac AMP-Activated Protein Kinase/Atrogin-1 Pathways Inhibit Charged Multivesicular Body Protein 2B Accumulation in Ischemia–Reperfusion Injury

Metformin-Enhanced Cardiac AMP-Activated Protein Kinase/Atrogin-1 Pathways Inhibit Charged Multivesicular Body Protein 2B Accumulation in Ischemia–Reperfusion Injury

Background: Cardiac autophagic flux is impaired during myocardial ischemia/reperfusion (MI/R). Impaired autophagic flux may exacerbate MI/R injury. Charged multivesicular body protein 2B (CHMP2B) is a subunit of the endosomal sorting complex required for transport (ESCRT-III) complex that is require...

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Bibliographic Details
Main Authors: Tian Li, Yue Yin, Nan Mu, Yishi Wang, Manling Liu, Mai Chen, Wenhua Jiang, Lu Yu, Yan Li, Heng Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
myocardial ischemia/reperfusion
metformin
autophagic flux
AMPK
atrogin-1
CHMP2B
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.621509/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.621509/full

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