In vitro and ex vitro functional characterization of human HLA-DRB1∗04 restricted T cell receptors

In vitro and ex vitro functional characterization of human HLA-DRB1∗04 restricted T cell receptors

Recent advances in single-cell sequencing technologies enable the generation of large-scale data sets of paired TCR sequences from patients with autoimmune disease. Methods to validate and characterize patient-derived TCR data are needed, as well as relevant model systems that can support the develo...

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Bibliographic Details
Main Authors: Sanjaykumar V. Boddul, Ravi Kumar Sharma, Anatoly Dubnovitsky, Bruno Raposo, Christina Gerstner, Yunbing Shen, Vaishnavi Srinivasan Iyer, Zsolt Kasza, William W. Kwok, Aaron R. Winkler, Lars Klareskog, Vivianne Malmström, Maria Bettini, Fredrik Wermeling
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Translational Autoimmunity
Subjects:
HLA
TCR
Cell lines
Humanized animal models
Tolerance
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909021000071

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http://www.sciencedirect.com/science/article/pii/S2589909021000071

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