Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process

Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process

Summary: CD4+ T cells play critical roles in directing immunity, both as T helper and as regulatory T (Treg) cells. Here, we demonstrate that hepatocytes can modulate T cell populations through engulfment of live CD4+ lymphocytes. We term this phenomenon enclysis to reflect the specific enclosure of...

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Bibliographic Details
Main Authors: Scott P. Davies, Gary M. Reynolds, Alex L. Wilkinson, Xiaoyan Li, Rebecca Rose, Maanav Leekha, Yuxin S. Liu, Ratnam Gandhi, Emma Buckroyd, Joe Grove, Nicholas M. Barnes, Robin C. May, Stefan G. Hubscher, David H. Adams, Yuehua Huang, Omar Qureshi, Zania Stamataki
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719312653

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http://www.sciencedirect.com/science/article/pii/S2211124719312653

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