Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases.

Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases.

Many complex human diseases are highly sexually dimorphic, suggesting a potential contribution of the X chromosome to disease risk. However, the X chromosome has been neglected or incorrectly analyzed in most genome-wide association studies (GWAS). We present tailored analytical methods and software...

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Bibliographic Details
Main Authors: Diana Chang, Feng Gao, Andrea Slavney, Li Ma, Yedael Y Waldman, Aaron J Sams, Paul Billing-Ross, Aviv Madar, Richard Spritz, Alon Keinan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4257614?pdf=render

Internet

http://europepmc.org/articles/PMC4257614?pdf=render

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