SREBP1 is required for the induction by glucose of pancreatic β-cell genes involved in glucose sensings⃞

SREBP1 is required for the induction by glucose of pancreatic β-cell genes involved in glucose sensings⃞

Previous studies have reported both positive and negative effects of culture of islets at high glucose concentrations on regulated insulin secretion. Here, we have reexamined this question in mouse islets and determined the role of changes in lipid synthesis in the effects of glucose. Glucose-stimul...

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Bibliographic Details
Main Authors: Frederique Diraison, Magalie A. Ravier, Sarah K. Richards, Richard M. Smith, Hitoshi Shimano, Guy A. Rutter
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Journal of Lipid Research
Subjects:
islets
sterol-regulatory element binding protein-1c
insulin secretion
pancreatic duodenal homeobox 1
triacsin C
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520423958

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http://www.sciencedirect.com/science/article/pii/S0022227520423958

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