Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

The specific Sirt1 activator SRT1720 increases mitochondrial function in skeletal muscle, presumably by activating Sirt1. However, Sirt1 gain of function does not increase mitochondrial function, which raises a question about the central role of Sirt1 in SRT1720 action. Moreover, it is believed that...

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Bibliographic Details
Main Authors: Sung-Jun Park, Faiyaz Ahmad, Jee-Hyun Um, Alexandra L. Brown, Xihui Xu, Hyeog Kang, Hengming Ke, Xuesong Feng, James Ryall, Andrew Philp, Simon Schenk, Myung K. Kim, Vittorio Sartorelli, Jay H. Chung
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:EBioMedicine
Subjects:
SRT1720
Phosphodiesterases
cAMP
AMPK
Sirt1
Epac
Type 2 diabetes
Obesity
Aging
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417301068

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http://www.sciencedirect.com/science/article/pii/S2352396417301068

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