Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws

Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws

Drug discovery frequently relies on the kinetic analysis of physicochemical reactions that are at the origin of the disease state. Amyloid fibril formation has been extensively investigated in relation to prevalent and rare neurodegenerative diseases, but thus far no therapeutic solution has directl...

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Bibliographic Details
Main Authors: Alexandra Silva, Zsuzsa Sárkány, Joana S. Fraga, Pablo Taboada, Sandra Macedo-Ribeiro, Pedro M. Martins
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Biomolecules
Subjects:
protein aggregation
amyloid
soluble oligomers
kinetic analysis
nucleation
Online Access:http://www.mdpi.com/2218-273X/8/4/108

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http://www.mdpi.com/2218-273X/8/4/108

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