In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting. Additionally, they report co-crystal structures of the variants bo...

Full description

Bibliographic Details
Main Authors: Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02565-5

Internet

https://doi.org/10.1038/s42003-021-02565-5

Similar Items