Comparison between Fractionated Dose and Single Dose of Cu-64 Trastuzumab Therapy in the NCI-N87 Gastric Cancer Mouse Model

Comparison between Fractionated Dose and Single Dose of Cu-64 Trastuzumab Therapy in the NCI-N87 Gastric Cancer Mouse Model

For optimum radioimmunotherapy (RIT), deep penetration and uniform distribution into the tumor core is important. The solid tumor microenvironment, consisting of a highly fibrotic or desmoplastic tumor, abnormal tumor vasculature, high fluid pressure, and the absence of fluid lymphatics, limits the...

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Bibliographic Details
Main Authors: Javeria Zaheer, Hyeongi Kim, Yong-Jin Lee, Sang Moo Lim, Jin Su Kim
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
radioimmunotherapy
single dose (SD)
fractional dose (FD)
penetration
therapeutics
Herceptin
trastuzumab
gastric cancer
Online Access:https://www.mdpi.com/1422-0067/20/19/4708

Internet

https://www.mdpi.com/1422-0067/20/19/4708

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