Bisdemethoxycurcumin Induces Apoptosis in Activated Hepatic Stellate Cells via Cannabinoid Receptor 2

Bisdemethoxycurcumin Induces Apoptosis in Activated Hepatic Stellate Cells via Cannabinoid Receptor 2

Activated Hepatic Stellate Cells (HSCs), major fibrogenic cells in the liver, undergo apoptosis when liver injuries cease, which may contribute to the resolution of fibrosis. Bisdemethoxycurcumin (BDMC) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities. The therap...

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Bibliographic Details
Main Authors: Phil Jun Lee, Seung Je Woo, Jun-Goo Jee, Sang Hyun Sung, Hong Pyo Kim
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
bisdemethoxycurcumin (BDMC)
curcumin
hepatic stellate cells (HSCs)
liver fibrosis
cannabinoid receptor (CBR) 2
death-inducing signaling complex (DISC)
adenosine triphosphate (ATP)
Online Access:http://www.mdpi.com/1420-3049/20/1/1277

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http://www.mdpi.com/1420-3049/20/1/1277

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