CB1R-Mediated Activation of Caspase-3 Causes Epigenetic and Neurobehavioral Abnormalities in Postnatal Ethanol-Exposed Mice

CB1R-Mediated Activation of Caspase-3 Causes Epigenetic and Neurobehavioral Abnormalities in Postnatal Ethanol-Exposed Mice

Alcohol exposure can affect brain development, leading to long-lasting behavioral problems, including cognitive impairment, which together is defined as fetal alcohol spectrum disorder (FASD). However, the fundamental mechanisms through which this occurs are largely unknown. In this study, we report...

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Bibliographic Details
Main Authors: Shivakumar Subbanna, Nagaraja N. Nagre, Madhu Shivakumar, Vikram Joshi, Delphine Psychoyos, Abdullah Kutlar, Nagavedi S. Umapathy, Balapal S. Basavarajappa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
MeCP2
FASD
neurodegeneration
DNA methylation
synaptic plasticity
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00045/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00045/full

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