The formyl peptide receptor agonist Ac2-26 alleviates neuroinflammation in a mouse model of pneumococcal meningitis

The formyl peptide receptor agonist Ac2-26 alleviates neuroinflammation in a mouse model of pneumococcal meningitis

Abstract Background Bacterial meningitis is still a cause of severe neurological disability. The brain is protected from penetrating pathogens by the blood-brain barrier and the innate immune system. The invading pathogens are recognized by pattern recognition receptors including the G-protein-coupl...

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Bibliographic Details
Main Authors: Marvin Rüger, Eugenia Kipp, Nadine Schubert, Nicole Schröder, Thomas Pufe, Matthias B. Stope, Markus Kipp, Christian Blume, Simone C. Tauber, Lars-Ove Brandenburg
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Bacterial meningitis
Formyl peptide receptor
Glial cell
Innate immunity
Streptococcus pneumoniae
Annexin A1
Online Access:http://link.springer.com/article/10.1186/s12974-020-02006-w

Internet

http://link.springer.com/article/10.1186/s12974-020-02006-w

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