Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1

Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1

Nef is an accessory protein encoded by human immunodeficiency virus type-1 (HIV-1) and plays important roles in regulating HIV-1 infection and viral replication. Interestingly, HIV-1 Nef can promote degradation of numerous host proteins to disrupt cellular antiviral immune response. However, how HIV...

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Bibliographic Details
Main Authors: Hong-Guang Zhang, Jing Guo, Yukang Yuan, Yibo Zuo, Jin Liu, Li Zhu, Ying Miao, Xiangjie Chen, Lincong Jin, Fan Huang, Tengfei Ren, Jiuyi He, Weifeng Shi, Zhenke Wen, Chuanwu Zhu, Hui Zheng, Chunsheng Dong, Feng Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Microbiology
Subjects:
c-Cbl
HIV-1
Nef
ubiquitination
E3 ubiquitin ligase
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.597972/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.597972/full

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