Compaction and segregation of sister chromatids via active loop extrusion
The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can robustly compact, segregate and disentangle c...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/14864 |