Compaction and segregation of sister chromatids via active loop extrusion

The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can robustly compact, segregate and disentangle c...

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Bibliographic Details
Main Authors: Anton Goloborodko, Maxim V Imakaev, John F Marko, Leonid Mirny
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/14864