Reversible and noisy progression towards a commitment point enables adaptable and reliable cellular decision-making.

Cells must make reliable decisions under fluctuating extracellular conditions, but also be flexible enough to adapt to such changes. How cells reconcile these seemingly contradictory requirements through the dynamics of cellular decision-making is poorly understood. To study this issue we quantitati...

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Bibliographic Details
Main Authors: Anna Kuchina, Lorena Espinar, Jordi Garcia-Ojalvo, Gürol M Süel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-11-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3213189?pdf=render