Short Lifespans of Memory T-cells in Bone Marrow, Blood, and Lymph Nodes Suggest That T-cell Memory Is Maintained by Continuous Self-Renewal of Recirculating Cells

Short Lifespans of Memory T-cells in Bone Marrow, Blood, and Lymph Nodes Suggest That T-cell Memory Is Maintained by Continuous Self-Renewal of Recirculating Cells

Memory T-cells are essential to maintain long-term immunological memory. It is widely thought that the bone marrow (BM) plays an important role in the long-term maintenance of memory T-cells. There is controversy however on the longevity and recirculating kinetics of BM memory T-cells. While some ha...

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Bibliographic Details
Main Authors: Mariona Baliu-Piqué, Myrddin W. Verheij, Julia Drylewicz, Lars Ravesloot, Rob J. de Boer, Ad Koets, Kiki Tesselaar, José A. M. Borghans
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
bone marrow
memory T-cells
lymphocyte turnover
lifespan
stable isotope labeling
deuterium
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02054/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02054/full

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