HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease

Abstract Background The worldwide pandemic caused by the SARS-CoV-2 virus is characterized by significant and unpredictable heterogeneity in symptoms that remains poorly understood. Methods Transcriptome and single cell transcriptome of COVID19 lung were integrated with deeplearning analysis of MHC...

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Bibliographic Details
Main Authors: Christophe Desterke, Ali G. Turhan, Annelise Bennaceur-Griscelli, Frank Griscelli
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Translational Medicine
Subjects:
HLA
Online Access:https://doi.org/10.1186/s12967-021-02965-5