RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells

RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells

All-trans retinoic acid (ATRA) has a key role in dendritic cells (DCs) and affects T cell subtype specification and gut homing. However, the identity of the permissive cell types and the required steps of conversion of vitamin A to biologically active ATRA bringing about retinoic acid receptor-regul...

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Bibliographic Details
Main Authors: Adrienn Gyöngyösi, Istvan Szatmari, Attila Pap, Balazs Dezső, Zoltan Pos, Lajos Széles, Tamas Varga, Laszlo Nagy
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Journal of Lipid Research
Subjects:
retinoid metabolism
retinoic acid receptor signaling
iNKT cells
lipid antigen presentation
lipid transport
cellular retinoic acid binding protein 2
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752035135X

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http://www.sciencedirect.com/science/article/pii/S002222752035135X

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