Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction <i>via</i> ROS Damage and Upregulation of HIF-1

Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction <i>via</i> ROS Damage and Upregulation of HIF-1

Combined androgen blockade using bicalutamide (Bic) is a therapeutic choice for treating prostate cancer (PCa). However, even at regular clinical dosages, Bic frequently shows adverse effects associated with cardiovascular and renal damage. Previously, we found that Bic selectively damaged mesangial...

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Bibliographic Details
Main Authors: Kuan-Chou Chen, Chang-Rong Chen, Chang-Yu Chen, Kai-Yi Tzou, Chiung-Chi Peng, Robert Y. Peng
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
bicalutamide (Bic)
rat mesangial cell (RMC) line
mitochondrial dysfunction
HIF-1
oxygen consumption rate (OCR)
Online Access:https://www.mdpi.com/1422-0067/21/9/3400

Internet

https://www.mdpi.com/1422-0067/21/9/3400

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