Exposure to endocrine disruptor induces transgenerational epigenetic deregulation of microRNAs in primordial germ cells.

Exposure to endocrine disruptor induces transgenerational epigenetic deregulation of microRNAs in primordial germ cells.

In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal development. Prenatal exposure to environmental toxicants such as endocrine disruptors may alter PGC differentiation, development of the male germline and induce transgenerational epigenetic disorders...

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Bibliographic Details
Main Authors: Miguel A Brieño-Enríquez, Jesús García-López, David B Cárdenas, Sylvain Guibert, Elouan Cleroux, Lukas Děd, Juan de Dios Hourcade, Jana Pěknicová, Michael Weber, Jesús Del Mazo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4405367?pdf=render

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http://europepmc.org/articles/PMC4405367?pdf=render

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