A Genetic Polymorphism in the <i>Pannexin1</i> Gene Predisposes for The Development of Endothelial Dysfunction with Increasing BMI

A Genetic Polymorphism in the <i>Pannexin1</i> Gene Predisposes for The Development of Endothelial Dysfunction with Increasing BMI

Endothelial dysfunction worsens when body mass index (BMI) increases. Pannexin1 (Panx1) ATP release channels regulate endothelial function and lipid homeostasis in mice. We investigated whether the Panx1-400A&gt;C single nucleotide polymorphism (SNP), encoding for a gain-of-function channel, ass...

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Bibliographic Details
Main Authors: Filippo Molica, Alessandra Quercioli, Fabrizio Montecucco, Thomas H. Schindler, Brenda R. Kwak, Sandrine Morel
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Biomolecules
Subjects:
panx1
polymorphism
endothelial function
obesity
Online Access:https://www.mdpi.com/2218-273X/10/2/208

Internet

https://www.mdpi.com/2218-273X/10/2/208

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