Structure of the active form of human origin recognition complex and its ATPase motor module

Structure of the active form of human origin recognition complex and its ATPase motor module

Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells. Here, we report the structure of the active form of human ORC determined by X-ray crystallography and cryo-electron microscopy. The c...

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Bibliographic Details
Main Authors: Ante Tocilj, Kin Fan On, Zuanning Yuan, Jingchuan Sun, Elad Elkayam, Huilin Li, Bruce Stillman, Leemor Joshua-Tor
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
replication
AAA+-ATPase
nucleic acids
Online Access:https://elifesciences.org/articles/20818

Internet

https://elifesciences.org/articles/20818

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