Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression

Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression

Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for migration. Targeting oncogenes involved in angiogenesis is needed to t...

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Bibliographic Details
Main Authors: Yunzhao Chen, Dandan Wang, Hao Peng, Xi Chen, Xueping Han, Jie Yu, Wenjie Wang, Lirong Liang, Zheng Liu, Yi Zheng, Jianming Hu, Lan Yang, Jun Li, Hong Zhou, Xiaobin Cui, Feng Li
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Molecular Cancer
Subjects:
Esophageal carcinoma
PLCE1
NF-κB
Angiogenesis
Proliferation
Online Access:http://link.springer.com/article/10.1186/s12943-018-0930-x

Internet

http://link.springer.com/article/10.1186/s12943-018-0930-x

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