The Polycomb BMI1 Protein Is Co-expressed With CD26+ in Leukemic Stem Cells of Chronic Myeloid Leukemia

The Polycomb BMI1 Protein Is Co-expressed With CD26+ in Leukemic Stem Cells of Chronic Myeloid Leukemia

The Polycomb gene BMI1 expression exerts a negative predictive impact on several hematological malignancies, such as acute and chronic myeloid leukemia (CML), myelofibrosis, and follicular lymphoma. As already demonstrated in CML, BMI1 is responsible for the resistance to the tyrosine kinase inhibit...

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Bibliographic Details
Main Authors: Sara Galimberti, Susanna Grassi, Claudia Baratè, Francesca Guerrini, Elena Ciabatti, Francesca Perutelli, Federica Ricci, Giada Del Genio, Marina Montali, Serena Barachini, Cecilia Giuliani, Maria Immacolata Ferreri, Angelo Valetto, Elisabetta Abruzzese, Chiara Ippolito, Alessandra Iurlo, Monica Bocchia, Anna Sicuranza, Bruno Martino, Lorenzo Iovino, Gabriele Buda, Serena Salehzadeh, Mario Petrini, Antonello Di Paolo, Letizia Mattii
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
BMI1
polycomb
BCR-ABL1
CML
CD26
leukemic stem cell
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00555/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00555/full

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