Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs

Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering of electrically and chemically responsive, contractile human muscle tissues (‘myobun...

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Bibliographic Details
Main Authors: Lauran Madden, Mark Juhas, William E Kraus, George A Truskey, Nenad Bursac
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/04885