Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2

Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2

Genome-wide association studies suggest that HLA-C expression is a major determinant of viral load set points and CD4+ T cell counts in HIV-infected individuals. On the one hand, efficient HLA-C expression enables the killing of infected cells by cytotoxic T lymphocytes (CTLs). On the other hand, HL...

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Bibliographic Details
Main Authors: Kristina Hopfensperger, Jonathan Richard, Christina M. Stürzel, Frederic Bibollet-Ruche, Richard Apps, Marie Leoz, Jean-Christophe Plantier, Beatrice H. Hahn, Andrés Finzi, Frank Kirchhoff, Daniel Sauter
Format: Article
Language:English
Published: American Society for Microbiology 2020-07-01
Series:mBio
Subjects:
hiv-1
hiv-2
siv
hla-c
vpu
vif
Online Access:https://doi.org/10.1128/mBio.00782-20

Internet

https://doi.org/10.1128/mBio.00782-20

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