Complement-mediated Damage to the Glycocalyx Plays a Role in Renal Ischemia-reperfusion Injury in Mice

Background. Complement activation plays an important role in the pathogenesis of renal ischemia-reperfusion (IR) injury (IRI), but whether this involves damage to the vasculoprotective endothelial glycocalyx is not clear. We investigated the impact of complement activation on glycocalyx integrity an...

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Bibliographic Details
Main Authors: Anjan K. Bongoni, PhD, Bo Lu, PhD, Jennifer L. McRae, PhD, Evelyn J. Salvaris, BSc (Hons), Erik J. M. Toonen, PhD, Ingela Vikstrom, PhD, Adriana Baz Morelli, PhD, Martin J. Pearse, PhD, Peter J. Cowan, PhD
Format: Article
Language:English
Published: Wolters Kluwer 2019-04-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000881