Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Abstract Background RING finger protein 38 (RNF38), a member of the RNF protein family, has just emerged as a vital driver of cancer progression. However, the oncogenic mechanisms of RNF38 remain unexplored. Methods Using frozen tumor tissue and tissue microarray from hepatocellular carcinoma (HCC)...

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Main Authors: Rui Peng, Peng-Fei Zhang, Xuan Yang, Chuan-Yuan Wei, Xiao-Yong Huang, Jia-Bin Cai, Jia-Cheng Lu, Chao Gao, Hai-Xiang Sun, Qiang Gao, Dou-Sheng Bai, Guo-Ming Shi, Ai-Wu Ke, Jia Fan
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
RNF38
AHNAK
TGF-β signaling
Prognosis
Online Access:http://link.springer.com/article/10.1186/s13046-019-1113-3

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http://link.springer.com/article/10.1186/s13046-019-1113-3

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