Anchoring Intrinsically Disordered Proteins to Multiple Targets: Lessons from N-Terminus of the p53 Protein

Anchoring Intrinsically Disordered Proteins to Multiple Targets: Lessons from N-Terminus of the p53 Protein

Anchor residues, which are deeply buried upon binding, play an important role in protein–protein interactions by providing recognition specificity and facilitating the binding kinetics. Up to now, studies on anchor residues have been focused mainly on ordered proteins. In this study, we investigated...

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Bibliographic Details
Main Authors: Yongqi Huang, Zhirong Liu
Format: Article
Language:English
Published: MDPI AG 2011-02-01
Series:International Journal of Molecular Sciences
Subjects:
anchor residue
intrinsically disordered proteins
binding promiscuity
molecular recognition features
p53
MDM2
Taz2
Online Access:http://www.mdpi.com/1422-0067/12/2/1410/

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http://www.mdpi.com/1422-0067/12/2/1410/

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