Network Analysis Identifies Sex-Specific Gene Expression Changes in Blood of Amyotrophic Lateral Sclerosis Patients

Network Analysis Identifies Sex-Specific Gene Expression Changes in Blood of Amyotrophic Lateral Sclerosis Patients

Understanding the molecular mechanisms underlying the pathogenesis of amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, is a major challenge. We used co-expression networks implemented by the SWitch Miner software to identify switch genes associated with drastic transcrip...

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Bibliographic Details
Main Authors: Jose A. Santiago, James P. Quinn, Judith A. Potashkin
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
ALS
blood
co-expression networks
neurodegeneration
switch genes
sex differences
Online Access:https://www.mdpi.com/1422-0067/22/13/7150

Internet

https://www.mdpi.com/1422-0067/22/13/7150

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