Engineering the human blood-brain barrier in vitro

Abstract The blood-brain barrier (BBB) is the interface between the vasculature and the brain, regulating molecular and cellular transport into the brain. Endothelial cells (ECs) that form the capillary walls constitute the physical barrier but are dependent on interactions with other cell types. In...

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Bibliographic Details
Main Authors: John J. Jamieson, Peter C. Searson, Sharon Gerecht
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Biological Engineering
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13036-017-0076-1