Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells

Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells

Abstract Background Shikonin (SKO) is a natural naphthoquinone derived from Chinese herbal medicine Arnebiae Radix with high development potentials due to its anti-inflammatory and anti-tumor activities. Overwhelming evidences have indicated that SKO can induce both necrosis and apoptosis in cancer...

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Bibliographic Details
Main Authors: Anqi Wang, Jiayu Liu, Yuhan Yang, Zhejie Chen, Caifang Gao, Zhanguo Wang, Chaomei Fu, Liang Zou, Shengpeng Wang
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Chinese Medicine
Subjects:
Shikonin
Breast cancer
Necrosis
Apoptosis
Ubiquitination
Online Access:https://doi.org/10.1186/s13020-021-00426-1

Internet

https://doi.org/10.1186/s13020-021-00426-1

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